Physical & Environmental Sciences  

Tim Causgrove

Associate Professor

Department of Physical & Environmental Sciences
Texas A&M University - Corpus Christi


How to reach me

Office Location: Room 207 Center for the Sciences
Office Phone: (361) 825-2399
E-mail:  tim.causgrove "at" tamucc.edu

S-Mail Address

6300 Ocean Drive, Unit 5802
College of Science & Technology
Texas A&M Univ. - Corpus Christi
Corpus Christi, TX 78412-5802

Office Hours:
Monday
 9-10 a.m.
 Note: These are times at which I will be in my office (or back in a couple minutes) and available to speak with you. I'm also usually around at a lot of other times;  you can call to see if I am in the office.
Tuesday
 1-3 p.m.
Wednesday 9-10 a.m.
Friday 9-10 a.m. Also available by appointment.
  

COURSES:

CHEM 1311 - General Chemistry I CHEM 4423 -Physical Chemistry I
CHEM 1312 - General Chemistry II CHEM 4424 - Physical Chemistry II
CHEM 4420 - Biophysical Chemistry


Research Interests:

Applications of spectroscopy to proteins, including the use of kinetic infrared and fluorescence spectroscopy to measure the time scale of protein folding.  Current projects include the use of “caged” compounds to initiate protein folding or functional events, which are measured by both kinetic and temperature-derivative methods.

Molecular modeling to simulate protein folding, including methods to simulate pH-induced protein folding in order to compare simulations with experimental results.

Selected Publications:

Timothy P. Causgrove and R. Brian Dyer (2006) "Non-equilibrium protein folding dynamics: Laser-induced pH-jump studies of the helix-coil transition", Chem. Phys. 323, 2-10
doi:10.1016/j.chemphys.2005.08.032

McMahon, B. H., Fabian, M., Tomson, F., Causgrove, T. P., Bailey, J. A., Rein, F. N., Dyer, R. B., Palmer, G., Gennis, R. B. & Woodruff, W. H. (2004) "FTIR studies of internal proton transfer reactions linked to inter-heme electron transfer in bovine cytochrome c oxidase" Biochim. Biophys. Acta 1655, 321-331.
doi:10.1016/j.bbabio.2004.01.007

Maness, S. J., Franzen, S., Gibbs, A. C., Causgrove, T. P. & Dyer, R. B. (2003) "Nanosecond temperature jump relaxation dynamics of cyclic beta-hairpin peptides" Biophys. J. 84, 3874-3882.

Williams, S., Causgrove, T. P., Gilmanshin, R., Fang, K. S., Callender, R. H., Woodruff, W. H. & Dyer, R. B. (1996) "Fast events in protein folding: helix melting and formation in a small peptide" Biochemistry 35, 691-697.

Causgrove, T. P. & Dyer, R. B. (1996) "Picosecond structural dynamics of myoglobin following photolysis of carbon monoxide" Journal of Physical Chemistry 100, 3273-3277.